Wiley_Advanced Science
Volume 9, Issue 7
March 4, 2022
Light-Triggered In Situ Biosynthesis of Artificial Melanin for Skin Protection (Adv. Sci. 7/2022)
Artificial Melanosome for Transdermal Delivery
In article number 2103503 by Uk-Jae Lee, Nathaniel S. Hwang, Byung-Gee Kim, and co-workers, light-triggered in situ biosynthesis of artificial melanin in native skin is proposed and demonstrated using photoactivatable tyrosinase. Photoactivatable tyrosinase is synthesized with site-specific incorporation of o-nitrobenzyl tyrosine and then encapsulated into lipid nanoparticles as an artificial melanosome for transdermal delivery. This biomimetic system can recapitulate the biosynthetic analogs of naturally occurring melanin.
- Uk-Jae Lee
- Junghyeon Ko
- Su-Hwan Kim
- Pyung-Gang Lee
- Young-Hyeon An
- Hyungdon Yun
- Dillon T. Flood
- Philip E. Dawson
- Nathaniel S. Hwang
- Byung-Gee Kim
Advanced Science: Vol 9, No 7 (wiley.com)
Image created by minjeong Kim / Nanosphere
Wiley_Advanced Science
Volume 9, Issue 7
March 4, 2022
Light-Triggered In Situ Biosynthesis of Artificial Melanin for Skin Protection (Adv. Sci. 7/2022)
Artificial Melanosome for Transdermal Delivery
In article number 2103503 by Uk-Jae Lee, Nathaniel S. Hwang, Byung-Gee Kim, and co-workers, light-triggered in situ biosynthesis of artificial melanin in native skin is proposed and demonstrated using photoactivatable tyrosinase. Photoactivatable tyrosinase is synthesized with site-specific incorporation of o-nitrobenzyl tyrosine and then encapsulated into lipid nanoparticles as an artificial melanosome for transdermal delivery. This biomimetic system can recapitulate the biosynthetic analogs of naturally occurring melanin.
Advanced Science: Vol 9, No 7 (wiley.com)
Image created by minjeong Kim / Nanosphere